Ontology highlight
ABSTRACT:
SUBMITTER: Kim DG
PROVIDER: S-EPMC4966428 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Kim Dong Geon DG Jin Younggeon Y Jin Juyoun J Yang Heekyoung H Joo Kyeung Min KM Lee Weon Sup WS Shim Sang Ryeol SR Kim Sung-Woo SW Yoo Jinsang J Lee Sang Hoon SH Yoo Jin-San JS Nam Do-Hyun DH
mAbs 20150901 6
Vascular endothelial growth factor (VEGF) and its receptors are considered the primary cause of tumor-induced angiogenesis. Specifically, VEGFR-2/kinase insert domain receptor (KDR) is part of the major signaling pathway that plays a significant role in tumor angiogenesis, which is associated with the development of various types of tumor and metastasis. In particular, KDR is involved in tumor angiogenesis as well as cancer cell growth and survival. In this study, we evaluated the therapeutic po ...[more]