Ontology highlight
ABSTRACT:
SUBMITTER: Nicod J
PROVIDER: S-EPMC4966644 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Nature genetics 20160704 8
Two bottlenecks impeding the genetic analysis of complex traits in rodents are access to mapping populations able to deliver gene-level mapping resolution and the need for population-specific genotyping arrays and haplotype reference panels. Here we combine low-coverage (0.15×) sequencing with a new method to impute the ancestral haplotype space in 1,887 commercially available outbred mice. We mapped 156 unique quantitative trait loci for 92 phenotypes at a 5% false discovery rate. Gene-level ma ...[more]