Ontology highlight
ABSTRACT:
SUBMITTER: Scheuer W
PROVIDER: S-EPMC4966847 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Scheuer Werner W Thomas Markus M Hanke Petra P Sam Johannes J Osl Franz F Weininger Diana D Baehner Monika M Seeber Stefan S Kettenberger Hubert H Schanzer Jürgen J Brinkmann Ulrich U Weidner K Michael KM Regula Jörg J Klein Christian C
mAbs 20160101 3
Vascular endothelial growth factor (VEGF)-A blockade has been validated clinically as a treatment for human cancers. Angiopoietin-2 (Ang-2) is a key regulator of blood vessel remodeling and maturation. In tumors, Ang-2 is up-regulated and an unfavorable prognostic factor. Recent data demonstrated that Ang-2 inhibition mediates anti-tumoral effects. We generated a tetravalent bispecific antibody (Ang-2-VEGF-TAvi6) targeting VEGF-A with 2 arms based on bevacizumab (Avastin®), and targeting Ang-2 w ...[more]