Adaptation to different types of stress converge on mitochondrial metabolism.

ABSTRACT: Yeast cell factories encounter physical and chemical stresses when used for industrial production of fuels and chemicals. These stresses reduce productivity and increase bioprocess costs. Understanding the mechanisms of the stress response is essential for improving cellular robustness in platform strains. We investigated the three most commonly encountered industrial stresses for yeast (ethanol, salt, and temperature) to identify the mechanisms of general and stress-specific responses under chemostat conditions in which specific growth rate-dependent changes are eliminated. By applying systems-level analysis, we found that most stress responses converge on mitochondrial processes. Our analysis revealed that stress-specific factors differ between applied stresses; however, they are underpi

SUBMITTER: Lahtvee PJ 

PROVIDER: S-EPMC4966989 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature