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Tissue-specific regulatory circuits reveal variable modular perturbations across complex diseases.

ABSTRACT: Mapping perturbed molecular circuits that underlie complex diseases remains a great challenge. We developed a comprehensive resource of 394 cell type- and tissue-specific gene regulatory networks for human, each specifying the genome-wide connectivity among transcription factors, enhancers, promoters and genes. Integration with 37 genome-wide association studies (GWASs) showed that disease-associated genetic variants--including variants that do not reach genome-wide significance--often perturb regulatory modules that are highly specific to disease-relevant cell types or tissues. Our resource opens the door to systematic analysis of regulatory programs across hundreds of human cell types and tissues (http://regulatorycircuits.org).

SUBMITTER: Marbach D

PROVIDER: S-EPMC4967716 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature

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Tissue-specific regulatory circuits reveal variable modular perturbations across complex diseases.

Marbach Daniel D Lamparter David D Quon Gerald G Kellis Manolis M Kutalik Zoltán Z Bergmann Sven S

Nature methods 20160307 4

Mapping perturbed molecular circuits that underlie complex diseases remains a great challenge. We developed a comprehensive resource of 394 cell type- and tissue-specific gene regulatory networks for human, each specifying the genome-wide connectivity among transcription factors, enhancers, promoters and genes. Integration with 37 genome-wide association studies (GWASs) showed that disease-associated genetic variants--including variants that do not reach genome-wide significance--often perturb r ...[more]

PMID: 26950747

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