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ABSTRACT:
SUBMITTER: Hasegawa A
PROVIDER: S-EPMC4968217 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Hasegawa Atsushi A Kaneko Hiroshi H Ishihara Daishi D Nakamura Masahiro M Watanabe Akira A Yamamoto Masayuki M Trainor Cecelia D CD Shimizu Ritsuko R
Molecular and cellular biology 20160729 16
GATA1 organizes erythroid and megakaryocytic differentiation by orchestrating the expression of multiple genes that show diversified expression profiles. Here, we demonstrate that GATA1 monovalently binds to a single GATA motif (Single-GATA) while a monomeric GATA1 and a homodimeric GATA1 bivalently bind to two GATA motifs in palindromic (Pal-GATA) and direct-repeat (Tandem-GATA) arrangements, respectively, and form higher stoichiometric complexes on respective elements. The amino-terminal zinc ...[more]