A Molecular Model for Lithium's Bioactive Form.
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ABSTRACT:
SUBMITTER: Briggs KT
PROVIDER: S-EPMC4968421 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Publications
A Molecular Model for Lithium's Bioactive Form.
Briggs Katharine T KT Giulian Gary G GG Li Gong G Kao Joseph P Y JPY Marino John P JP
Biophysical journal 20160701 2
Lithium carbonate, a drug for the treatment of bipolar disorder, provides mood stability to mitigate recurrent episodes of mania and/or depression. Despite its long-term and widespread use, the mechanism by which lithium acts to elicit these psychological changes has remained unknown. Using nuclear magnetic resonance (NMR) methods, in this study we characterized the association of lithium with adenosine triphosphate (ATP) and identified a bimetallic (Mg·Li) ATP complex. Lithium's affinity to for ...[more]
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