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Urine Protein/Creatinine Ratios during Labor: A Prospective Observational Study.


ABSTRACT: To evaluate the utility of urine protein/creatinine ratio (uPCR) measurements among healthy parturients at term we performed a prospective cohort study at a community teaching hospital.Serial urine samples were collected. Ninety-three women contributed 284 urine samples. uPCRs were determined. Multiple imputation and paired sampled analysis was performed when appropriate.Two-thirds (63/93) of women had at least one measured uPCR ? 0.3. One-third (31/93) had a uPCR ? 0.3 at admission, including 39.1% (9/23) of women not in labor. Median (IQR) uPCRs increased during labor and after delivery: latent phase/no labor, 0.15 (0.06-0.32); active phase, 0.29 (0.10-0.58); early postpartum, 0.45 (0.18-1.36) (all p < 0.04). Median uPCRs were significantly < 0.3 in the latent phase and significantly > 0.3 in the immediate postpartum period (p < 0.01). Women who labored before cesarean delivery had the highest early postpartum uPCRs: median (IQR) 1.16 (0.39-1.80). A negative urine dipstick protein result did not exclude uPCR ? 0.3. uPCRs were similar when compared by method of urine collection.uPCR ? 0.3 is common among healthy women with uncomplicated pregnancies at term. uPCR increases during labor and is not a reliable measure of pathologic proteinuria at term or during the peripartum period.

SUBMITTER: Tanamai VW 

PROVIDER: S-EPMC4968820 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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<h4>Purpose</h4>To evaluate the utility of urine protein/creatinine ratio (uPCR) measurements among healthy parturients at term we performed a prospective cohort study at a community teaching hospital.<h4>Methods</h4>Serial urine samples were collected. Ninety-three women contributed 284 urine samples. uPCRs were determined. Multiple imputation and paired sampled analysis was performed when appropriate.<h4>Results</h4>Two-thirds (63/93) of women had at least one measured uPCR ≥ 0.3. One-third (3  ...[more]

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