The integrin αv-TGFβ signaling axis is necessary for epidermal proliferation during cutaneous wound healing.

ABSTRACT: Proliferation and migration of epidermal keratinocytes are essential for proper cutaneous wound closure after injury. αv integrins and several of their ligands-vitronectin, TGFβ and thrombospondin-are up-regulated in healing wounds. However, the role of αv integrins in wound re-epithelialization is unknown. Here, we show that genetic depletion or antibody-mediated blockade of pan-integrin αv, or the specific heterodimer αvβ6, in keratinocytes limited epidermal proliferation at the wound edge and prevented re-epithelialization of wounded human organotypic skin both in vivo and in vitro. While we did not observe a migration defect upon αv blockade in vivo, αv was necessary for keratinocyte migration over longer distances in organotypic skin. Integrin αv is required for local activation of la

SUBMITTER: Duperret EK 

PROVIDER: S-EPMC4968969 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature