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Trajectories of self-reported cognitive function in postmenopausal women during adjuvant systemic therapy for breast cancer.


ABSTRACT: In a sample of 368 postmenopausal women, we (1) determined within-cohort and between-cohort relationships between adjuvant systemic therapy for breast cancer and self-reported cognitive function during the first 18 months of therapy and (2) evaluated the influence of co-occurring symptoms, neuropsychological function, and other covariates on relationships.We evaluated self-reported cognitive function, using the Patient Assessment of Own Functioning Inventory (PAOFI), and potential covariates (e.g., co-occurring symptom scores and neuropsychological function z-scores) in 158 women receiving aromatase inhibitor (AI) therapy alone, 104 women receiving chemotherapy followed by AI therapy, and 106 non-cancer controls. Patients were assessed before systemic therapy and then every 6 months, for a total of four assessments over 18 months. Controls were assessed at matched time points. Mixed-effects modeling was used to determine longitudinal relationships.Controlling for covariates, patients enrolled before chemotherapy reported poorer global cognitive function (p?

SUBMITTER: Merriman JD 

PROVIDER: S-EPMC4969219 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature

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Trajectories of self-reported cognitive function in postmenopausal women during adjuvant systemic therapy for breast cancer.

Merriman John D JD   Sereika Susan M SM   Brufsky Adam M AM   McAuliffe Priscilla F PF   McGuire Kandace P KP   Myers Jamie S JS   Phillips Mary L ML   Ryan Christopher M CM   Gentry Amanda L AL   Jones Lindsay D LD   Bender Catherine M CM  

Psycho-oncology 20151020 1


<h4>Objective</h4>In a sample of 368 postmenopausal women, we (1) determined within-cohort and between-cohort relationships between adjuvant systemic therapy for breast cancer and self-reported cognitive function during the first 18 months of therapy and (2) evaluated the influence of co-occurring symptoms, neuropsychological function, and other covariates on relationships.<h4>Methods</h4>We evaluated self-reported cognitive function, using the Patient Assessment of Own Functioning Inventory (PA  ...[more]

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2011-06-17 | GSE30010 | GEO