Ontology highlight
ABSTRACT:
SUBMITTER: Komatsu S
PROVIDER: S-EPMC4969400 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Komatsu Shuhei S Ichikawa Daisuke D Kawaguchi Tsutomu T Miyamae Mahito M Okajima Wataru W Ohashi Takuma T Imamura Taisuke T Kiuchi Jun J Konishi Hirotaka H Shiozaki Atsushi A Fujiwara Hitoshi H Okamoto Kazuma K Otsuji Eigo E
American journal of cancer research 20160701 7
Only a few studies indentified the significance of circulating microRNAs in blood as a predictive biomarker for chemoresistance in esophageal squamous cell carcinoma (ESCC). In this study, we tested whether oncogenic miR-21 promoted chemoresistance in ESCC and served as a biomarker for predicting chemoresistance in plasma of patients with ESCC. All consecutive patients underwent the preoperative chemotherapy regimen (JCOG9907 trial) with cisplatin plus 5-fluorouracil. As a result, pretreatment p ...[more]