Ontology highlight
ABSTRACT:
SUBMITTER: Bournazos S
PROVIDER: S-EPMC4970321 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Bournazos Stylianos S Gazumyan Anna A Seaman Michael S MS Nussenzweig Michel C MC Ravetch Jeffrey V JV
Cell 20160601 7
Broadly neutralizing antibodies (bNAbs) against the HIV-1 envelope glycoprotein (Env) suppress viremia in animal models of HIV-1 and humans. To achieve potent activity without the emergence of viral escape mutants, co-administration of different bNAbs is necessary to target distinct epitopes essential for viral fitness. Here, we report the development of bispecific anti-Env neutralizing antibodies (biNAbs) with potent activity. Synergistic activity of biNAbs was achieved by combining an engineer ...[more]