Ontology highlight
ABSTRACT:
SUBMITTER: Kan SH
PROVIDER: S-EPMC4970944 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Kan Shih-Hsin SH Le Steven Q SQ Bui Quang D QD Benedict Braeden B Cushman Jesse J Sands Mark S MS Dickson Patricia I PI
Behavioural brain research 20160623
Sanfilippo B syndrome is a progressive neurological disorder caused by inability to catabolize heparan sulfate glycosaminoglycans. We studied neurobehavior in male Sanfilippo B mice and heterozygous littermate controls from 16 to 20 weeks of age. Affected mice showed reduced anxiety, with a decrease in the number of stretch-attend postures during the elevated plus maze (p=0.001) and an increased tendency to linger in the center of an open field (p=0.032). Water maze testing showed impaired spati ...[more]