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A simultaneous diagnosis and genotyping method for global surveillance of cetacean morbillivirus.


ABSTRACT: Cetacean morbillivirus (CeMV) is considered one of the most important viral pathogens in cetaceans. CeMV outbreaks of lethal disease have repeatedly been observed in Europe, the Americas, and Australia, while large herds of gregarious species were found to be the likely reservoirs and sources of CeMV infection to susceptible species in the Atlantic and Pacific Oceans. Furthermore, three new strains were detected recently in Hawaii, Brazil and Australia. To clarify the real global distribution of CeMV and possible carriers, we showed a novel technique successfully diagnosing and distinguishing different virus strains (DMV, PWMV and novel CeMVs) using FFPE samples from 1996 to 2011. This efficient method that combines qRT-PCR and high resolution melting (HRM) could be applied to the future retrospective global studies for better understanding of different prevalence and outbreak conditions among ocean basins and the mechanism of variable host response to pathogens.

SUBMITTER: Yang WC 

PROVIDER: S-EPMC4971491 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature

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A simultaneous diagnosis and genotyping method for global surveillance of cetacean morbillivirus.

Yang Wei-Cheng WC   Wu Bi-Jhen BJ   Sierra Eva E   Fernandez Antonio A   Groch Kátia R KR   Catão-Dias José Luiz JL   West Kristi K   Chan Kun-Wei KW  

Scientific reports 20160803


Cetacean morbillivirus (CeMV) is considered one of the most important viral pathogens in cetaceans. CeMV outbreaks of lethal disease have repeatedly been observed in Europe, the Americas, and Australia, while large herds of gregarious species were found to be the likely reservoirs and sources of CeMV infection to susceptible species in the Atlantic and Pacific Oceans. Furthermore, three new strains were detected recently in Hawaii, Brazil and Australia. To clarify the real global distribution of  ...[more]

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