Ontology highlight
ABSTRACT:
SUBMITTER: Contreras-Jurado C
PROVIDER: S-EPMC4971531 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Contreras-Jurado Constanza C Alonso-Merino Elvira E Saiz-Ladera Cristina C Valiño Arturo José AJ Regadera Javier J Alemany Susana S Aranda Ana A
Scientific reports 20160803
Decreased thyroidal hormone production is found during lipopolysaccharide (LPS)-induced endotoxic shock in animals as well as in critically ill patients. Here we studied the role of the thyroid hormone receptors (TRs) in activation of STAT3, NF-κB and ERK, which play a key role in the response to inflammatory cytokines during sepsis. TR knockout mice showed down-regulation of hepatic inflammatory mediators, including interleukin 6 (IL-6) in response to LPS. Paradoxically, STAT3 and ERK activity ...[more]