Label-free optical quantification of structural alterations in Alzheimer's disease.
Ontology highlight
ABSTRACT:
SUBMITTER: Lee M
PROVIDER: S-EPMC4971571 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Publications
Label-free optical quantification of structural alterations in Alzheimer's disease.
Lee Moosung M Lee Eeksung E Jung JaeHwang J Yu Hyeonseung H Kim Kyoohyun K Yoon Jonghee J Lee Shinhwa S Jeong Yong Y Park YongKeun Y
Scientific reports 20160803
We present a wide-field quantitative label-free imaging of mouse brain tissue slices with sub-micrometre resolution, employing holographic microscopy and an automated scanning platform. From the measured light field images, scattering coefficients and anisotropies are quantitatively retrieved by using the modified the scattering-phase theorem, which enables access to structural information about brain tissues. As a proof of principle, we demonstrate that these scattering parameters enable us to ...[more]
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