Ontology highlight
ABSTRACT:
SUBMITTER: Manchanda H
PROVIDER: S-EPMC4971777 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Manchanda Himanshu H Seidel Nora N Blaess Markus F MF Claus Ralf A RA Linde Joerg J Slevogt Hortense H Sauerbrei Andreas A Guthke Reinhard R Schmidtke Michaela M
Frontiers in microbiology 20160803
Severe influenza associated with strong symptoms and lung inflammation can be caused by intra-host evolution of quasispecies with aspartic acid or glycine in hemagglutinin position 222 (HA-222D/G; H1 numbering). To gain insights into the dynamics of host response to this coevolution and to identify key mechanisms contributing to copathogenesis, the lung transcriptional response of BALB/c mice infected with an A(H1N1)pdm09 isolate consisting HA-222D/G quasispecies was analyzed from days 1 to 12 p ...[more]