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Mechanized azobenzene-functionalized zirconium metal-organic framework for on-command cargo release.

ABSTRACT: Stimuli-responsive metal-organic frameworks (MOFs) have gained increasing attention recently for their potential applications in many areas. We report the design and synthesis of a water-stable zirconium MOF (Zr-MOF) that bears photoresponsive azobenzene groups. This particular MOF can be used as a reservoir for storage of cargo in water, and the cargo-loaded MOF can be further capped to construct a mechanized MOF through the binding of ?-cyclodextrin with the azobenzene stalks on the MOF surface. The resulting mechanized MOF has shown on-command cargo release triggered by ultraviolet irradiation or addition of competitive agents without premature release. This study represents a simple approach to the construction of stimuli-responsive mechanized MOFs, and considering mechanized UiO-68-azo made from biocompatible components, this smart system may provide a unique MOF platform for on-command drug delivery in the future.

SUBMITTER: Meng X

PROVIDER: S-EPMC4972467 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature

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Mechanized azobenzene-functionalized zirconium metal-organic framework for on-command cargo release.

Meng Xiangshi X Gui Bo B Yuan Daqiang D Zeller Matthias M Wang Cheng C

Science advances 20160803 8

Stimuli-responsive metal-organic frameworks (MOFs) have gained increasing attention recently for their potential applications in many areas. We report the design and synthesis of a water-stable zirconium MOF (Zr-MOF) that bears photoresponsive azobenzene groups. This particular MOF can be used as a reservoir for storage of cargo in water, and the cargo-loaded MOF can be further capped to construct a mechanized MOF through the binding of β-cyclodextrin with the azobenzene stalks on the MOF surfac ...[more]

PMID: 27493996

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