Ontology highlight
ABSTRACT:
SUBMITTER: Tsuchiya Y
PROVIDER: S-EPMC4972534 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
EBioMedicine 20160601
The innate immune protein Stimulator of interferon genes (STING) promotes the induction of interferon beta (IFN-β) production via the phosphorylation of its C-terminal tail (CTT) by TANK-binding kinase 1 (TBK1). Potent ligands of STING are, therefore, promising candidates for novel anti-cancer drugs or vaccine adjuvants. However, the intrinsically flexible CTT poses serious problems in in silico drug discovery. Here, we performed molecular dynamics simulations of the STING fragment containing th ...[more]