Activation of PPAR? by a Natural Flavonoid Modulator, Apigenin Ameliorates Obesity-Related Inflammation Via Regulation of Macrophage Polarization.

ABSTRACT: PPAR? has emerged as a master regulator of macrophage polarization and is the molecular target of the thiazolidinedione drugs. Here we show that apigenin binds and activates PPAR? by acting as a modulator. Activation of PPAR? by apigenin blocks p65 translocation into nuclei through inhibition of p65/PPAR? complex translocation into nuclei, thereby decreasing NF-?B activation and favoringM2 macrophage polarization. In HFD and ob/ob mice, apigenin significantly reverses M1 macrophage into M2 and reduces the infiltration of inflammatory cells in liver and adipose tissues, as well as decreases the levels of pro-inflammatory cytokines, thereby alleviating inflammation. Strikingly, apigenin reduces liver and muscular steatosis, decreases the levels of ALT, AST, TC and TG, improving glucose resistance obviously. Unlike rosiglitazone, apigenin does not cause significant weight gain, osteoporosis et al. Our findings identify apigenin as a modulator of PPAR? and a potential lead compound for treatment of metabolic disorders.

SUBMITTER: Feng X 

PROVIDER: S-EPMC4972579 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature