Ontology highlight
ABSTRACT:
SUBMITTER: Kurimchak AM
PROVIDER: S-EPMC4972668 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Kurimchak Alison M AM Shelton Claude C Duncan Kelly E KE Johnson Katherine J KJ Brown Jennifer J O'Brien Shane S Gabbasov Rashid R Fink Lauren S LS Li Yuesheng Y Lounsbury Nicole N Abou-Gharbia Magid M Childers Wayne E WE Connolly Denise C DC Chernoff Jonathan J Peterson Jeffrey R JR Duncan James S JS
Cell reports 20160721 5
Small-molecule BET bromodomain inhibitors (BETis) are actively being pursued in clinical trials for the treatment of a variety of cancers, but the mechanisms of resistance to BETis remain poorly understood. Using a mass spectrometry approach that globally measures kinase signaling at the proteomic level, we evaluated the response of the kinome to targeted BETi treatment in a panel of BRD4-dependent ovarian carcinoma (OC) cell lines. Despite initial inhibitory effects of BETi, OC cells acquired r ...[more]