Ontology highlight
ABSTRACT:
SUBMITTER: Incio J
PROVIDER: S-EPMC4972679 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Incio Joao J Liu Hao H Suboj Priya P Chin Shan M SM Chen Ivy X IX Pinter Matthias M Ng Mei R MR Nia Hadi T HT Grahovac Jelena J Kao Shannon S Babykutty Suboj S Huang Yuhui Y Jung Keehoon K Rahbari Nuh N NN Han Xiaoxing X Chauhan Vikash P VP Martin John D JD Kahn Julia J Huang Peigen P Desphande Vikram V Michaelson James J Michelakos Theodoros P TP Ferrone Cristina R CR Soares Raquel R Boucher Yves Y Fukumura Dai D Jain Rakesh K RK
Cancer discovery 20160531 8
<h4>Unlabelled</h4>It remains unclear how obesity worsens treatment outcomes in patients with pancreatic ductal adenocarcinoma (PDAC). In normal pancreas, obesity promotes inflammation and fibrosis. We found in mouse models of PDAC that obesity also promotes desmoplasia associated with accelerated tumor growth and impaired delivery/efficacy of chemotherapeutics through reduced perfusion. Genetic and pharmacologic inhibition of angiotensin-II type-1 receptor reverses obesity-augmented desmoplasia ...[more]