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CATCHR, HOPS and CORVET tethering complexes share a similar architecture.

ABSTRACT: We show here that the Saccharomyces cerevisiae GARP complex and the Cog1-4 subcomplex of the COG complex, both members of the complexes associated with tethering containing helical rods (CATCHR) family of multisubunit tethering complexes, share the same subunit organization. We also show that HOPS, a tethering complex acting in the endolysosomal pathway, shares a similar architecture, thus suggesting that multisubunit tethering complexes use related structural frameworks.

SUBMITTER: Chou HT

PROVIDER: S-EPMC4972687 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature

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CATCHR, HOPS and CORVET tethering complexes share a similar architecture.

Chou Hui-Ting HT Dukovski Danijela D Chambers Melissa G MG Reinisch Karin M KM Walz Thomas T

Nature structural & molecular biology 20160718 8

We show here that the Saccharomyces cerevisiae GARP complex and the Cog1-4 subcomplex of the COG complex, both members of the complexes associated with tethering containing helical rods (CATCHR) family of multisubunit tethering complexes, share the same subunit organization. We also show that HOPS, a tethering complex acting in the endolysosomal pathway, shares a similar architecture, thus suggesting that multisubunit tethering complexes use related structural frameworks. ...[more]

PMID: 27428774

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