Ontology highlight
ABSTRACT:
SUBMITTER: Borromeo MD
PROVIDER: S-EPMC4972690 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Borromeo Mark D MD Savage Trisha K TK Kollipara Rahul K RK He Min M Augustyn Alexander A Osborne Jihan K JK Girard Luc L Minna John D JD Gazdar Adi F AF Cobb Melanie H MH Johnson Jane E JE
Cell reports 20160721 5
Small cell lung carcinoma (SCLC) is a high-grade pulmonary neuroendocrine tumor. The transcription factors ASCL1 and NEUROD1 play crucial roles in promoting malignant behavior and survival of human SCLC cell lines. Here, we find that ASCL1 and NEUROD1 identify heterogeneity in SCLC, bind distinct genomic loci, and regulate mostly distinct genes. ASCL1, but not NEUROD1, is present in mouse pulmonary neuroendocrine cells, and only ASCL1 is required in vivo for tumor formation in mouse models of SC ...[more]