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Untangling the Manganese-?-Synuclein Web.

ABSTRACT: Neurodegenerative diseases affect a significant portion of the aging population. Several lines of evidence suggest a positive association between environmental exposures, which are common and cumulative in a lifetime, and development of neurodegenerative diseases. Environmental or occupational exposure to manganese (Mn) has been implicated in neurodegeneration due to its ability to induce mitochondrial dysfunction, oxidative stress, and ?-synuclein (?-Syn) aggregation. The role of the ?-Syn protein vis-a-vis Mn is controversial, as it seemingly plays a duplicitous role in neuroprotection and neurodegeneration. ?-Syn has low affinity for Mn, however an indirect interaction cannot be ruled out. In this review we will examine the current knowledge surrounding the interaction of ?-Syn and Mn in neurodegenerative process.

SUBMITTER: Peres TV

PROVIDER: S-EPMC4972813 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Untangling the Manganese-α-Synuclein Web.

Peres Tanara Vieira TV Parmalee Nancy L NL Martinez-Finley Ebany J EJ Aschner Michael M

Frontiers in neuroscience 20160804

Neurodegenerative diseases affect a significant portion of the aging population. Several lines of evidence suggest a positive association between environmental exposures, which are common and cumulative in a lifetime, and development of neurodegenerative diseases. Environmental or occupational exposure to manganese (Mn) has been implicated in neurodegeneration due to its ability to induce mitochondrial dysfunction, oxidative stress, and α-synuclein (α-Syn) aggregation. The role of the α-Syn prot ...[more]

PMID: 27540354

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