Ontology highlight
ABSTRACT:
SUBMITTER: Fuso A
PROVIDER: S-EPMC4972849 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Fuso A A Iyer A M AM van Scheppingen J J Maccarrone M M Scholl T T Hainfellner J A JA Feucht M M Jansen F E FE Spliet W G WG Krsek P P Zamecnik J J Mühlebner A A Aronica E E
Journal of molecular neuroscience : MN 20160428 4
In tuberous sclerosis complex (TSC), overexpression of numerous genes associated with inflammation has been observed. Among different proinflammatory cytokines, interleukin-1β (IL-1β) has been shown to be significantly involved in epileptogenesis and maintenance of seizures. Recent evidence indicates that IL-1β gene expression can be regulated by DNA methylation of its promoter. In the present study, we hypothesized that hypomethylation in the promoter region of the IL-1β gene may underlie its o ...[more]