The association of three promoter polymorphisms in interleukin-10 gene with the risk for colorectal cancer and hepatocellular carcinoma: A meta-analysis.

ABSTRACT: Mounting evidence supports a potent inhibitory role of interleukin-10 (IL-10) in tumor carcinogenesis, angiogenesis and metastasis. This meta-analysis was designed to examine the association of three promoter polymorphisms (-592C?>?A, -819C?>?T and -1082G?>?A) in IL-10 gene with the risk for colorectal cancer and hepatocellular carcinoma. Qualification assessment and data collection were completed by two authors independently. The random-effects model using the DerSimonian and Laird method was fitted by the STATA software. Twenty-five articles involving 5933 cases and 9724 controls were meta-analyzed. Overall comparisons of the mutant alleles (-592A, -819T and -1082A) of three promoter polymorphisms with alternative wild alleles failed to reveal any statistical significance for both colorectal cancer and hepatocellular carcinoma (P?>?0.05), and the likelihood of heterogeneity was low (I(2)??A polymorphism, a significant risk for colorectal cancer was identified when analysis was restricted to East Asians (odds ratio or OR?=?1.41, 95% confidence interval or CI: 1.18-1.68, P??A polymorphism in IL-10 gene might be a susceptibility locus for colorectal cancer in East Asians.

SUBMITTER: Shi YH 

PROVIDER: S-EPMC4973248 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature