Ontology highlight
ABSTRACT:
SUBMITTER: Yang Y
PROVIDER: S-EPMC4973249 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Yang Yu Y Liu Fang F Tang Miao M Yuan Miner M Hu Andina A Zhan Zongyi Z Li Zijing Z Li Jiaqing J Ding Xiaoyan X Lu Lin L
Scientific reports 20160804
Macrophages play an important role in the development of age-related macular degeneration (AMD). In this study, the spatial and temporal changes and the polarization of macrophages in murine laser-induced choroidal neovascularization (CNV) were investigated, and the polarized M1 and M2 biomarkers in the aqueous humors of neovascular AMD (nAMD) patients were studied. Macrophages, the main infiltrating inflammatory cells in CNV lesions, were evidenced by a significant increase in F4/80 mRNA expres ...[more]