Ontology highlight
ABSTRACT:
SUBMITTER: Kim C
PROVIDER: S-EPMC4973277 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Kim Changyoun C Lv Guohua G Lee Jun Sung JS Jung Byung Chul BC Masuda-Suzukake Masami M Hong Chul-Suk CS Valera Elvira E Lee He-Jin HJ Paik Seung R SR Hasegawa Masato M Masliah Eliezer E Eliezer David D Lee Seung-Jae SJ
Scientific reports 20160804
A single amyloidogenic protein is implicated in multiple neurological diseases and capable of generating a number of aggregate "strains" with distinct structures. Among the amyloidogenic proteins, α-synuclein generates multiple patterns of proteinopathies in a group of diseases, such as Parkinson disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). However, the link between specific conformations and distinct pathologies, the key concept of the strain hypothesis, rem ...[more]