Ontology highlight
ABSTRACT:
SUBMITTER: Jego S
PROVIDER: S-EPMC4974078 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Jego Sonia S Glasgow Stephen D SD Herrera Carolina Gutierrez CG Ekstrand Mats M Reed Sean J SJ Boyce Richard R Friedman Jeffrey J Burdakov Denis D Adamantidis Antoine R AR
Nature neuroscience 20130922 11
Rapid-eye movement (REM) sleep correlates with neuronal activity in the brainstem, basal forebrain and lateral hypothalamus. Lateral hypothalamus melanin-concentrating hormone (MCH)-expressing neurons are active during sleep, but their effects on REM sleep remain unclear. Using optogenetic tools in newly generated Tg(Pmch-cre) mice, we found that acute activation of MCH neurons (ChETA, SSFO) at the onset of REM sleep extended the duration of REM, but not non-REM, sleep episodes. In contrast, the ...[more]