Ontology highlight
ABSTRACT:
SUBMITTER: Cho DY
PROVIDER: S-EPMC4974081 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Cho Doo-Yeoun DY Shen Joan H Q JH Lemler Suzanne M SM Skaar Todd C TC Li Lang L Blievernicht Julia J Zanger Ulrich M UM Kim Kwon-Bok KB Shin Jae-Gook JG Flockhart David A DA Desta Zeruesenay Z
Drug metabolism and pharmacokinetics 20150729 2
The effect of rifampin on the in vivo metabolism of the antiretroviral drug efavirenz was evaluated in healthy volunteers. In a cross-over placebo control trial, healthy subjects (n = 20) were administered a single 600 mg oral dose of efavirenz after pretreatment with placebo or rifampin (600 mg/day for 10 days). Plasma and urine concentrations of efavirenz, 8-hydroxyefavirenz and 8,14-dihydroxyefavirenz were measured by LC-MS/MS. Compared to placebo treatment, rifampin increased the oral cleara ...[more]