Ontology highlight
ABSTRACT:
SUBMITTER: Weider E
PROVIDER: S-EPMC4974380 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Weider Elodie E Susan-Resiga Delia D Essalmani Rachid R Hamelin Josée J Asselin Marie-Claude MC Nimesh Surendra S Ashraf Yahya Y Wycoff Keith L KL Zhang Jianbing J Prat Annik A Seidah Nabil G NG
The Journal of biological chemistry 20160608 32
Single domain antibodies (sdAbs) correspond to the antigen-binding domains of camelid antibodies. They have the same antigen-binding properties and specificity as monoclonal antibodies (mAbs) but are easier and cheaper to produce. We report here the development of sdAbs targeting human PCSK9 (proprotein convertase subtilisin/kexin type 9) as an alternative to anti-PCSK9 mAbs. After immunizing a llama with human PCSK9, we selected four sdAbs that bind PCSK9 with a high affinity and produced them ...[more]