Simultaneous targeted activation of Notch1 and Vhl-disruption in the kidney proximal epithelial tubular cells in mice.
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ABSTRACT:
SUBMITTER: Johansson E
PROVIDER: S-EPMC4974510 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Publications
Simultaneous targeted activation of Notch1 and Vhl-disruption in the kidney proximal epithelial tubular cells in mice.
Johansson Elinn E Rönö Birgitte B Johansson Martin M Lindgren David D Möller Christina C Axelson Håkan H Smith Emma M K EM
Scientific reports 20160805
Clear cell renal cell carcinoma (ccRCC) is the most common subtype of kidney cancer, representing approximately 75% of all renal neoplasms. ccRCC is known to be strongly associated with silencing of the von Hippel Lindau (VHL) tumor suppressor gene, yet VHL deficiency alone does not seem to be sufficient to drive the oncogenic transformation of normal renal epithelium and induce renal tumorigenesis. We, and others, have previously suggested that constitutive activation of the Notch signaling pat ...[more]
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