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Ameloblastoma Phenotypes Reflected in Distinct Transcriptome Profiles.

ABSTRACT: Ameloblastoma is a locally invasive benign neoplasm derived from odontogenic epithelium and presents with diverse phenotypes yet to be characterized molecularly. High recurrence rates of 50-80% with conservative treatment in some sub-types warrants radical surgical resections resulting in high morbidity. The objective of the study was to characterize the transcriptome of ameloblastoma and identify relevant genes and molecular pathways using normal odontogenic tissue (human "dentome") for comparison. Laser capture microdissection was used to obtain neoplastic epithelial tissue from 17 tumors which were examined using the Agilent 44?k whole genome microarray. Ameloblastoma separated into 2 distinct molecular clusters that were associated with pre-secretory ameloblast and odontoblast. Within the pre-secretory cluster, 9/10 of samples were of the follicular type while 6/7 of the samples in the odontoblast cluster were of the plexiform type (p?

SUBMITTER: Hu S

PROVIDER: S-EPMC4974613 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature

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Ameloblastoma Phenotypes Reflected in Distinct Transcriptome Profiles.

Hu Shijia S Parker Joel J Divaris Kimon K Padilla Ricardo R Murrah Valerie V Wright John Timothy JT

Scientific reports 20160805

Ameloblastoma is a locally invasive benign neoplasm derived from odontogenic epithelium and presents with diverse phenotypes yet to be characterized molecularly. High recurrence rates of 50-80% with conservative treatment in some sub-types warrants radical surgical resections resulting in high morbidity. The objective of the study was to characterize the transcriptome of ameloblastoma and identify relevant genes and molecular pathways using normal odontogenic tissue (human "dentome") for compari ...[more]

PMID: 27491308

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Ameloblastoma Phenotypes Reflected in Distinct Transcriptome Profiles.

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Ameloblastoma Phenotypes Reflected in Distinct Transcriptome Profiles.

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