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Regulation of B-cell development and tolerance by different members of the miR-17?92 family microRNAs.

ABSTRACT: The molecular mechanisms that regulate B-cell development and tolerance remain incompletely understood. In this study, we identify a critical role for the miR-17?92 microRNA cluster in regulating B-cell central tolerance and demonstrate that these miRNAs control early B-cell development in a cell-intrinsic manner. While the cluster member miR-19 suppresses the expression of Pten and plays a key role in regulating B-cell tolerance, miR-17 controls early B-cell development through other molecular pathways. These findings demonstrate differential control of two closely linked B-cell developmental stages by different members of a single microRNA cluster through distinct molecular pathways.

SUBMITTER: Lai M

PROVIDER: S-EPMC4974641 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature

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Regulation of B-cell development and tolerance by different members of the miR-17∼92 family microRNAs.

Lai Maoyi M Gonzalez-Martin Alicia A Cooper Anthony B AB Oda Hiroyo H Jin Hyun Yong HY Shepherd Jovan J He Linling L Zhu Jiang J Nemazee David D Xiao Changchun C

Nature communications 20160802

The molecular mechanisms that regulate B-cell development and tolerance remain incompletely understood. In this study, we identify a critical role for the miR-17∼92 microRNA cluster in regulating B-cell central tolerance and demonstrate that these miRNAs control early B-cell development in a cell-intrinsic manner. While the cluster member miR-19 suppresses the expression of Pten and plays a key role in regulating B-cell tolerance, miR-17 controls early B-cell development through other molecular ...[more]

PMID: 27481093

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