Patterns of Kidney Function Decline Associated with APOL1 Genotypes: Results from AASK.

ABSTRACT:

Background and objectives

Trajectories of eGFR in patients with CKD are highly variable. Only a subset of patients with CKD experiences a steady decline in eGFR. The objective of our study was to investigate whether eGFR trajectory patterns differ by APOL1 risk status.

Design, setting, participants, & measurements

Our study was a longitudinal observational study of 622 participants in the African American Study of Kidney Disease and Hypertension with APOL1 genotyping and sufficient follow-up for estimating GFR trajectories. The predictor was APOL1 high-risk status (having two copies of the G1 or G2 risk alleles) versus low-risk status (zero or one copy of the risk alleles), and the outcome was four eGFR trajectory patterns on the basis of the joint probabilities of linearity

SUBMITTER: Tin A 

PROVIDER: S-EPMC4974891 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature