Ontology highlight
ABSTRACT:
SUBMITTER: Silva PJ
PROVIDER: S-EPMC4974919 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
PeerJ 20160728
1,2-dihydro-1,2-azaborine is a structural and electronic analogue of benzene which is able to occupy benzene-binding pockets in T4 lysozyme and has been proposed as suitable arene-mimicking group for biological and pharmaceutical applications. Its applicability in a biological context requires it to be able to resist modification by xenobiotic-degrading enzymes like the P450 cytochromes. Quantum chemical computations described in this work show that 1,2-dihydro-1,2-azaborine is much more prone t ...[more]