Ontology highlight
ABSTRACT:
SUBMITTER: Li Z
PROVIDER: S-EPMC4975166 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Molecular pharmaceutics 20160203 3
Cocrystallization is a technique to optimize solid forms that shows great potential to improve the solubility of active pharmaceutical ingredients (APIs). In some systems, an API can form cocrystals in multiple stoichiometries with the same coformer. However, it remains unclear how coformer stoichiometry influences solubility. This paper investigates the pharmaceutical:coformer pair carbamazepine (CBZ)/p-aminobenzoic acid (PABA); both CBZ/PABA 1:1 and 2:1 cocrystals are known, and a novel 4:1 CB ...[more]