Ontology highlight
ABSTRACT:
SUBMITTER: Li J
PROVIDER: S-EPMC4975501 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
PLoS computational biology 20160805 8
The knowledge of the tertiary structure of RNA loops is important for understanding their functions. In this work we develop an efficient approach named RNApps, specifically designed for predicting the tertiary structure of RNA loops, including hairpin loops, internal loops, and multi-way junction loops. It includes a probabilistic coarse-grained RNA model, an all-atom statistical energy function, a sequential Monte Carlo growth algorithm, and a simulated annealing procedure. The approach is tes ...[more]