Realizing the promise of cancer predisposition genes.
Ontology highlight
ABSTRACT:
SUBMITTER: Rahman N
PROVIDER: S-EPMC4975511 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Publications
Genes in which germline mutations confer highly or moderately increased risks of cancer are called cancer predisposition genes. More than 100 of these genes have been identified, providing important scientific insights in many areas, particularly the mechanisms of cancer causation. Moreover, clinical utilization of cancer predisposition genes has had a substantial impact on diagnosis, optimized management and prevention of cancer. The recent transformative advances in DNA sequencing hold the pro ...[more]
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