Targeting CBLB as a potential therapeutic approach for disseminated candidiasis.
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ABSTRACT:
SUBMITTER: Xiao Y
PROVIDER: S-EPMC4975523 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Publications
Targeting CBLB as a potential therapeutic approach for disseminated candidiasis.
Xiao Yun Y Tang Juan J Guo Hui H Zhao Yixia Y Tang Rong R Ouyang Song S Zeng Qiuming Q Rappleye Chad A CA Rajaram Murugesan V S MV Schlesinger Larry S LS Tao Lijian L Brown Gordon D GD Langdon Wallace Y WY Li Belinda T BT Zhang Jian J
Nature medicine 20160718 8
Disseminated candidiasis has become one of the leading causes of hospital-acquired blood stream infections with high mobility and mortality. However, the molecular basis of host defense against disseminated candidiasis remains elusive, and treatment options are limited. Here we report that the E3 ubiquitin ligase CBLB directs polyubiquitination of dectin-1 and dectin-2, two key pattern-recognition receptors for sensing Candida albicans, and their downstream kinase SYK, thus inhibiting dectin-1- ...[more]
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