Ontology highlight
ABSTRACT:
SUBMITTER: Chai SC
PROVIDER: S-EPMC4975625 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Chai Sergio C SC Cherian Milu T MT Wang Yue-Ming YM Chen Taosheng T
Biochimica et biophysica acta 20160224 9
Two nuclear receptors, the pregnane X receptor (PXR) and the constitutive androstane receptor (CAR), participate in the xenobiotic detoxification system by regulating the expression of drug-metabolizing enzymes and transporters in order to degrade and excrete foreign chemicals or endogenous metabolites. This review aims to expand the perceived relevance of PXR and CAR beyond their established role as master xenosensors to disease-oriented areas, emphasizing their modulation by small molecules. S ...[more]