Dataset Information

Novel correlates between antimullerian hormone and menstrual cycle characteristics in African-American women (23-35 years-old).

ABSTRACT: OBJECTIVE:To characterize normative antimüllerian hormone (AMH) levels and ascertain which factors are associated with AMH in a large cohort of reproductive-age women. DESIGN:Cross-sectional study. SETTING:Not applicable. PATIENT(S):A total of 1,654 African-American women (AAW) ages 23-34 at recruitment. INTERVENTION(S):Not applicable. MAIN OUTCOME MEASURE(S):Serum AMH measured using an ultrasensitive ELISA. RESULT(S):The median AMH was 3.18 ng/mL, and there was a significant, but nonlinear, relationship between age and AMH, with levels peaking at age 25. As AMH was not normally distributed, log transformation was performed and used for all analyses. In a multivariable age-adjusted model, body mass index, current use of hormonal contraception, and history of a thyroid condition were inversely associated with AMH, while history of abnormal menstrual bleeding and menstrual cycles longer than 35 days were positively associated with AMH. CONCLUSION(S):While age is correlated with AMH, it accounts for only a portion of the variation seen. This study adds valuable information to the existing literature on normative AMH levels in young reproductive-age women. While our findings fill a critical data gap for ovarian reserve in AAW, the insights gained will be of benefit for all women.

SUBMITTER: Marsh EE

PROVIDER: S-EPMC4975664 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature

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Novel correlates between antimüllerian hormone and menstrual cycle characteristics in African-American women (23-35 years-old).

Marsh Erica E EE Bernardi Lia A LA Steinberg Marissa L ML de Chavez Peter J PJ Visser Jenny A JA Carnethon Mercedes R MR Baird Donna D DD

Fertility and sterility 20160423 2

<h4>Objective</h4>To characterize normative antimüllerian hormone (AMH) levels and ascertain which factors are associated with AMH in a large cohort of reproductive-age women.<h4>Design</h4>Cross-sectional study.<h4>Setting</h4>Not applicable.<h4>Patient(s)</h4>A total of 1,654 African-American women (AAW) ages 23-34 at recruitment.<h4>Intervention(s)</h4>Not applicable.<h4>Main outcome measure(s)</h4>Serum AMH measured using an ultrasensitive ELISA.<h4>Result(s)</h4>The median AMH was 3.18 ng/m ...[more]

PMID: 27114331

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Project description:Study questionIs soy formula feeding during infancy associated with menstrual pain in reproductive-age women?Summary answerOur data suggest that soy formula feeding during infancy is associated with several indicators of severe menstrual pain in reproductive-age women.What is known alreadyA prior study observed greater severity of menstrual pain in young women who as infants participated in feeding studies and were assigned to soy-based formula feeding.Study design, size, durationWe used data from the Study of Environment, Lifestyle & Fibroids (SELF), a cohort of 1696 African-American women ages 23-35 years at enrollment.Participants/materials, settings, methodsData on infant soy formula feeding was ascertained by self-administered questionnaire for 1553 participants, with 89% of participants receiving assistance from their mothers. Information on menstrual pain indicators was collected by web- and telephone-interview. We estimated the relative risk (RR) and 95% confidence interval (CI) using log-binomial regression, or log-multinomial regression, adjusting for participant age and maternal education.Main results and the role of chanceWomen ever fed soy formula as infants were more likely than unexposed women to report ever use of hormonal contraception for menstrual pain (RR 1.4, CI: 1.1-1.9) and moderate/severe menstrual discomfort/pain with 'most periods', but not 'every period', during early adulthood (ages 18-22 when not using hormonal contraception) (RR 1.5, CI: 1.1-2.0).Limitations, reasons for cautionWe relied on retrospective recall to ascertain infant exposure to soy formula feeding and data on menstrual pain indicators.Wider implications of the findingsOur observations add to the growing body of literature from animal and human studies on the reproductive health consequences of early-life exposure to soy formula.Study funding/competing interest(s)This research was supported by the Intramural Research Program of the NIH, National Institute of Environmental Health Sciences and, in part, by funds allocated for health research by the American Recovery and Reinvestment Act. This research was also supported by grant K99NR017191 (KU). None of the authors has a conflict of interest.Trial registration numberNot applicable.

Project description:PurposeMenstrual cycle characteristics are markers of endocrine milieu. However, associations between age at menarche and adulthood sex steroid hormone levels have been inconsistent, and data on menstrual characteristics and non-sex steroid hormones are sparse.MethodsWe assessed the relations of menstrual characteristics with premenopausal plasma sex steroid hormones, sex hormone binding globulin (SHBG), prolactin, and growth factors among 2,745 premenopausal women (age 32-52) from the Nurses' Health Study II. Geometric means and tests for trend were calculated using multivariable general linear models.ResultsEarly age at menarche was associated with higher premenopausal early-follicular free estradiol (percent difference < 12 vs. > 13 years = 11%), early-follicular estrone (7%), luteal estrone (7%), and free testosterone (8%) (all p trend < 0.05). Short menstrual cycle length at age 18-22 was associated with higher early-follicular total (< 26 vs. > 39 days = 18%) and free estradiol (16%), early-follicular estrone (9%), SHBG (7%), lower luteal free estradiol (- 14%), total (- 6%), and free testosterone (- 15%) (all p trend < 0.05). Short adult menstrual length was associated with higher early-follicular total estradiol (< 26 vs. > 31 days = 14%), SHBG (10%), lower luteal estrone (- 8%), progesterone (- 9%), total (- 11%) and free testosterone (- 25%), and androstenedione (- 14%) (all p trend < 0.05). Irregularity of menses at 18-22 was associated with lower early-follicular total (irregular vs. very regular = - 14%) and free estradiol (- 14%), and early-follicular estrone (- 8%) (All p trend < 0.05). Irregularity of adult menstrual cycle was associated with lower luteal total estradiol (irregular vs. very regular = - 8%), SHBG (- 3%), higher total (8%), and free testosterone (11%) (all p trend < 0.05).ConclusionsEarly-life and adulthood menstrual characteristics are moderately associated with mid-to-late reproductive year's hormone concentrations. These relations of menstrual characteristics with endogenous hormone levels could partially account for associations between menstrual characteristics and reproductive cancers or other chronic diseases.

Dataset Information

Novel correlates between antimullerian hormone and menstrual cycle characteristics in African-American women (23-35 years-old).

Publications

Novel correlates between antimüllerian hormone and menstrual cycle characteristics in African-American women (23-35 years-old).

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