Ontology highlight
ABSTRACT:
SUBMITTER: Metskas LA
PROVIDER: S-EPMC4976047 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Journal of molecular biology 20160706 15
The troponin complex is a molecular switch that ties shifting intracellular calcium concentration to association and dissociation of actin and myosin, effectively allowing excitation-contraction coupling in striated muscle. Although there is a long history of muscle biophysics and structural biology, many of the mechanistic details that enable troponin's function remain incompletely understood. This review summarizes the current structural understanding of the troponin complex on the muscle thin ...[more]