Serum metabolomic signatures discriminate early liver inflammation and fibrosis stages in patients with chronic hepatitis B.
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ABSTRACT:
SUBMITTER: Huang H
PROVIDER: S-EPMC4976343 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
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Serum metabolomic signatures discriminate early liver inflammation and fibrosis stages in patients with chronic hepatitis B.
Huang Haijun H Sun Zeyu Z Pan Hongying H Chen Meijuan M Tong Yongxi Y Zhang Jiajie J Chen Deying D Su Xiaoling X Li Lanjuan L
Scientific reports 20160808
Chronic HBV (CHB) infected patients with intermediate necroinflammation and fibrosis are recommended to receive antiviral treatment. However, other than liver biopsy, there is a lack of sensitive and specific objective method to determine the necroinflammation and fibrosis stages in CHB patients. This study aims to identify unique serum metabolomic profile associated with histological progression in CHB patients and to develop novel metabolite biomarker panels for early CHB detection and stratif ...[more]
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