Ontology highlight
ABSTRACT:
SUBMITTER: Blanchard N
PROVIDER: S-EPMC4976627 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Blanchard Nicolas N Gonzalez Federico F Schaeffer Marie M Joncker Nathalie T NT Cheng Tiffany T Shastri Anjali J AJ Robey Ellen A EA Shastri Nilabh N
Nature immunology 20080629 8
The parasite Toxoplasma gondii replicates in a specialized intracellular vacuole and causes disease in many species. Protection from toxoplasmosis is mediated by CD8(+) T cells, but the T. gondii antigens and host genes required for eliciting protective immunity are poorly defined. Here we identified GRA6, a polymorphic protein secreted in the parasitophorous vacuole, as the source of the immunodominant and protective decapeptide HF10 presented by the H-2L(d) major histocompatibility complex cla ...[more]