Ontology highlight
ABSTRACT:
SUBMITTER: Chastain M
PROVIDER: S-EPMC4976776 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Chastain Megan M Zhou Qing Q Shiva Olga O Fadri-Moskwik Maria M Whitmore Leanne L Jia Pingping P Dai Xueyu X Huang Chenhui C Ye Ping P Chai Weihang W
Cell reports 20160801 5
The telomeric CTC1/STN1/TEN1 (CST) complex has been implicated in promoting replication recovery under replication stress at genomic regions, yet its precise role is unclear. Here, we report that STN1 is enriched at GC-rich repetitive sequences genome-wide in response to hydroxyurea (HU)-induced replication stress. STN1 deficiency exacerbates the fragility of these sequences under replication stress, resulting in chromosome fragmentation. We find that upon fork stalling, CST proteins form distin ...[more]