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Vaccinia virus, a promising new therapeutic agent for pancreatic cancer.

ABSTRACT: The poor prognosis of pancreatic cancer patients signifies a need for radically new therapeutic strategies. Tumor-targeted oncolytic viruses have emerged as attractive therapeutic candidates for cancer treatment due to their inherent ability to specifically target and lyse tumor cells as well as induce antitumor effects by multiple action mechanisms. Vaccinia virus has several inherent features that make it particularly suitable for use as an oncolytic agent. In this review, we will discuss the potential of vaccinia virus in the management of pancreatic cancer in light of our increased understanding of cellular and immunological mechanisms involved in the disease process as well as our extending knowledge in the biology of vaccinia virus.

SUBMITTER: Al Yaghchi C

PROVIDER: S-EPMC4976866 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Vaccinia virus, a promising new therapeutic agent for pancreatic cancer.

Al Yaghchi Chadwan C Zhang Zhongxian Z Alusi Ghassan G Lemoine Nicholas R NR Wang Yaohe Y

Immunotherapy 20151123 12

The poor prognosis of pancreatic cancer patients signifies a need for radically new therapeutic strategies. Tumor-targeted oncolytic viruses have emerged as attractive therapeutic candidates for cancer treatment due to their inherent ability to specifically target and lyse tumor cells as well as induce antitumor effects by multiple action mechanisms. Vaccinia virus has several inherent features that make it particularly suitable for use as an oncolytic agent. In this review, we will discuss the ...[more]

PMID: 26595180

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