Etiological Subgroups of Small-for-Gestational-Age: Differential Neurodevelopmental Outcomes.

ABSTRACT:

Objectives

It remains unclear why substantial variations in neurodevelopmental outcomes exist within small-for-gestational-age (SGA) children. We prospectively compared 5-y neurodevelopmental outcomes across SGA etiological subgroups.

Methods

Children born SGA (N = 1050) from U.S. Early Childhood Longitudinal Study-Birth Cohort (2001-2007) was divided into etiological subgroups by each of 7 well-established prenatal risk factors. We fit linear regression models to compare 5-y reading, math, gross motor and fine motor scores across SGA subgroups, adjusting for socio-demographic confounders.

Results

Compared to singleton SGA subgroup, multiple-birth SGA subgroup had lower mean reading (adjusted mean difference, -4.08 [95% confidence interval, -6.10, -2.06]) and math (-2

SUBMITTER: Li X 

PROVIDER: S-EPMC4976943 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature