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PediHaplotyper: software for consistent assignment of marker haplotypes in pedigrees.


ABSTRACT: In the study of large outbred pedigrees with many founders, individual bi-allelic markers, such as SNP markers, carry little information. After phasing the marker genotypes, multi-allelic loci consisting of groups of closely linked markers can be identified, which are called "haploblocks". Here, we describe PediHaplotyper, an R package capable of assigning consistent alleles to such haploblocks, allowing for missing and incorrect SNP data. These haploblock genotypes are much easier to interpret by the human investigator than the original SNP data and also allow more efficient QTL analyses that require less memory and computation time.

SUBMITTER: Voorrips RE 

PROVIDER: S-EPMC4977329 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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PediHaplotyper: software for consistent assignment of marker haplotypes in pedigrees.

Voorrips Roeland E RE   Bink Marco C A M MC   Kruisselbrink Johannes W JW   Koehorst-van Putten Herma J J HJ   van de Weg W Eric WE  

Molecular breeding : new strategies in plant improvement 20160808


In the study of large outbred pedigrees with many founders, individual bi-allelic markers, such as SNP markers, carry little information. After phasing the marker genotypes, multi-allelic loci consisting of groups of closely linked markers can be identified, which are called "haploblocks". Here, we describe PediHaplotyper, an R package capable of assigning consistent alleles to such haploblocks, allowing for missing and incorrect SNP data. These haploblock genotypes are much easier to interpret  ...[more]

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